•MAME 0.78 (multiple arcade systems; standalone version 0.125)
•FBA Alpha (multiple systems including: Neo Geo, CPS-1, CPS-2, CPS-3, Sega System 16 and System 18)
•ProSystem (Atari 7800)
•Virtual Jaguar (Atari Jaguar)
•Handy / MEd nafen Handy (Atari Lynx)
•GW (Game & Watch)
•O2EM (Odyssey 2, Videopac+)
•FCEU-MM (NES/Famicom)
•QuickNES (NES/Famicom)
•Nestopia (NES/Famicom, Nintendo Disk System)
•SNEX9x Next (SNES)
•Gambatte (Game Boy, Game Boy Color)
•Genesis Plus GX (Sega Genesis/Mega Drive, Sega/Mega CD [bios required], Game Gear, SG-1000)
•Mednafen NGP (NeoGeo Pocket and Pocket Color)
•Mednafen FX (PC-FX)
•Mednafen PCE Fast (Turbo Grafx 16 / CD, PC Engine, Super Grafx) [bios required]
•Mednafen VB (Nintendo Virtual Boy)
•Mednafen WonderSwan (WonderSwan)
•NXEngine (Cave Story Engine)
•PRBoom (Doom, Doom II Engine)
•Stella (Atari 2600)
•VBA Next (Game Boy Advance)
•TyrQuake (Quake)
•VecX (Vectrex)
Если для игры требуется BIOS, то его нужно собственноручно поместить в папку "/dev_hdd0/game/SSNE10000/USRDIR/cores/system/".